Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration

Trisomy 21 (T21), Down Syndrome (DS) is the most common genetic cause of dementia and intellectual disability. Modeling DS is beginning to yield pharmaceutical therapeutic interventions for amelioration of intellectual disability, which are currently being tested in clinical trials. DS is also a uni...

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Publicat a:Stem Cells
Autors principals: Murray, Aoife, Letourneau, Audrey, Canzonetta, Claudia, Stathaki, Elisavet, Gimelli, Stefania, Sloan‐Bena, Frederique, Abrehart, Robert, Goh, Pollyanna, Lim, Shuhui, Baldo, Chiara, Dagna‐Bricarelli, Franca, Hannan, Saad, Mortensen, Martin, Ballard, David, Syndercombe Court, Denise, Fusaki, Noemi, Hasegawa, Mamoru, Smart, Trevor G., Bishop, Cleo, Antonarakis, Stylianos E., Groet, Jürgen, Nizetic, Dean
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
Matèries:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737213/
https://ncbi.nlm.nih.gov/pubmed/25694335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1968
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