Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases

MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a catalytic role for Tyr126 and approach of the...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Woods, Ryan D., O'Shea, Valerie L., Chu, Aurea, Cao, Sheng, Richards, Jody L., Horvath, Martin P., David, Sheila S.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
Nucleic Acid Enzymes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737165/
https://ncbi.nlm.nih.gov/pubmed/26673696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1469
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