BET protein inhibitor JQ1 inhibits growth and modulates WNT signaling in mesenchymal stem cells

BACKGROUND: Efficacy and safety of anticancer drugs are traditionally studied using cancer cell lines and animal models. The thienodiazepine class of BET inhibitors, such as JQ1, has been extensively studied for the potential treatment of hematological malignancies and several small molecules belong...

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Bibliografiske detaljer
Udgivet i:Stem Cell Res Ther
Main Authors: Alghamdi, Saeed, Khan, Irfan, Beeravolu, Naimisha, McKee, Christina, Thibodeau, Bryan, Wilson, George, Chaudhry, G. Rasul
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736146/
https://ncbi.nlm.nih.gov/pubmed/26830473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-016-0278-3
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