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Restored expression of vitamin D receptor and sensitivity to 1,25-dihydroxyvitamin D(3) in response to disrupted fusion FOP2–FGFR1 gene in acute myeloid leukemia cells
BACKGROUND: Acute myeloid leukemia (AML) cells can be induced to undergo terminal differentiation with subsequent loss of tumorigenicity using 1,25-dihydroxyvitamin D(3) (1,25D) alone or in combination with hematopoietic cytokines. KG1 cells are resistant to 1,25D-induced cell differentiation. These...
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| Published in: | Cell Biosci |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4735962/ https://ncbi.nlm.nih.gov/pubmed/26839680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-016-0075-9 |
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