Case report: Severe central nervous system manifestations associated with aberrant efavirenz metabolism in children: the role of CYP2B6 genetic variation

BACKGROUND: Efavirenz, widely used as part of antiretroviral drug regimens in the treatment of paediatric human immunodeficiency virus infection, has central nervous system side effects. We describe four children presenting with serious, persistent central nervous system adverse events who were foun...

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Detalhes bibliográficos
Publicado no:BMC Infect Dis
Main Authors: Pinillos, Francoise, Dandara, Collet, Swart, Marelize, Strehlau, Renate, Kuhn, Louise, Patel, Faeezah, Coovadia, Ashraf, Abrams, Elaine
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735961/
https://ncbi.nlm.nih.gov/pubmed/26831894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-016-1381-x
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