Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2

In chronic kidney disease (CKD), proteinuria results in severe tubulointerstitial lesions, which ultimately lead to end-stage renal disease. Here we identify 4-phenylbutyric acid (PBA), a chemical chaperone already used in humans, as a novel therapeutic strategy capable to counteract the toxic effec...

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Udgivet i:Nat Commun
Main Authors: El Karoui, Khalil, Viau, Amandine, Dellis, Olivier, Bagattin, Alessia, Nguyen, Clément, Baron, William, Burtin, Martine, Broueilh, Mélanie, Heidet, Laurence, Mollet, Géraldine, Druilhe, Anne, Antignac, Corinne, Knebelmann, Bertrand, Friedlander, Gérard, Bienaimé, Frank, Gallazzini, Morgan, Terzi, Fabiola
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735759/
https://ncbi.nlm.nih.gov/pubmed/26787103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10330
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