Discovery of gene-gene interactions across multiple independent datasets of Late Onset Alzheimer Disease from the Alzheimer Disease Genetics Consortium

Late-onset Alzheimer disease (LOAD) has a complex genetic etiology, involving locus heterogeneity, polygenic inheritance and gene-gene interactions; however, the investigation of interactions in recent GWAS has been limited. We used a biological knowledge-driven approach to evaluate gene-gene intera...

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Vydáno v:Neurobiol Aging
Hlavní autoři: Hohman, Timothy J., Bush, William S., Jiang, Lan, Brown-Gentry, Kristin D., Torstenson, Eric S., Dudek, Scott M., Mukherjee, Shubhabrata, Naj, Adam, Kunkle, Brian W., Ritchie, Marylyn D., Martin, Eden R., Schellenberg, Gerard D., Mayeux, Richard, Farrer, Lindsay A., Pericak-Vance, Margaret A., Haines, Jonathan L., Thornton-Wells, Tricia A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735733/
https://ncbi.nlm.nih.gov/pubmed/26827652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.10.031
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