Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6

Triple-negative breast cancer (TNBC) exhibits innate resistance to the EGFR inhibition despite high level expression of EGFR. Recently, we found that the proliferation of basal-like (BL) subtype TNBC cells is synergistically inhibited by combination of EGFR and PI3K/AKT inhibitors. On the contrary,...

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Vydáno v:Int J Oncol
Hlavní autoři: YI, YONG WEON, YOU, KYUSIC, BAE, EDWARD JEONG, KWAK, SAHNG-JUNE, SEONG, YEON-SUN, BAE, INSOO
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2015
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735702/
https://ncbi.nlm.nih.gov/pubmed/25955731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2015.2982
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