Inhibition of the PI3K/AKT pathway potentiates cytotoxicity of EGFR kinase inhibitors in triple-negative breast cancer cells

Triple-negative breast cancers (TNBCs) are known to be intrinsically resistant to inhibitors for epidermal growth factor receptor (EGFR). Until now, clinical trials for TNBCs using EGFR inhibitors (EGFRis) as single agents have yielded disappointing results. Here, we report that combinatorial treatm...

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Detalhes bibliográficos
Main Authors: Yi, Yong Weon, Hong, Wooyoung, Kang, Hyo Jin, Kim, Hee Jeong, Zhao, Wenjing, Wang, Antai, Seong, Yeon-Sun, Bae, Insoo
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822817/
https://ncbi.nlm.nih.gov/pubmed/23601074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12046
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