Inhibition of the PI3K/AKT pathway potentiates cytotoxicity of EGFR kinase inhibitors in triple-negative breast cancer cells

Triple-negative breast cancers (TNBCs) are known to be intrinsically resistant to inhibitors for epidermal growth factor receptor (EGFR). Until now, clinical trials for TNBCs using EGFR inhibitors (EGFRis) as single agents have yielded disappointing results. Here, we report that combinatorial treatm...

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Bibliographische Detailangaben
Hauptverfasser: Yi, Yong Weon, Hong, Wooyoung, Kang, Hyo Jin, Kim, Hee Jeong, Zhao, Wenjing, Wang, Antai, Seong, Yeon-Sun, Bae, Insoo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2013
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822817/
https://ncbi.nlm.nih.gov/pubmed/23601074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12046
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