New observations on maternal age effect on germline de novo mutations

Germline mutations are the source of evolution and contribute substantially to many health-related processes. Here we use whole-genome deep sequencing data from 693 parents–offspring trios to examine the de novo point mutations (DNMs) in the offspring. Our estimate for the mutation rate per base pai...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wong, Wendy S. W., Solomon, Benjamin D., Bodian, Dale L., Kothiyal, Prachi, Eley, Greg, Huddleston, Kathi C., Baker, Robin, Thach, Dzung C., Iyer, Ramaswamy K., Vockley, Joseph G., Niederhuber, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735694/
https://ncbi.nlm.nih.gov/pubmed/26781218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10486
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