Germline Variation in Cancer-Susceptibility Genes in a Healthy, Ancestrally Diverse Cohort: Implications for Individual Genome Sequencing

Technological advances coupled with decreasing costs are bringing whole genome and whole exome sequencing closer to routine clinical use. One of the hurdles to clinical implementation is the high number of variants of unknown significance. For cancer-susceptibility genes, the difficulty in interpret...

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Detalhes bibliográficos
Main Authors: Bodian, Dale L., McCutcheon, Justine N., Kothiyal, Prachi, Huddleston, Kathi C., Iyer, Ramaswamy K., Vockley, Joseph G., Niederhuber, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984285/
https://ncbi.nlm.nih.gov/pubmed/24728327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094554
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