TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage

RAP80 localizes to sites of DNA insults to enhance the DNA-damage responses. Here we identify TRAIP/RNF206 as a novel RAP80-interacting protein and find that TRAIP is necessary for translocation of RAP80 to DNA lesions. Depletion of TRAIP results in impaired accumulation of RAP80 and functional down...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Soo Lee, Nam, Jin Chung, Hee, Kim, Hyoung-June, Yun Lee, Seo, Ji, Jae-Hoon, Seo, Yoojeong, Hun Han, Seung, Choi, Minji, Yun, Miyong, Lee, Seok-Geun, Myung, Kyungjae, Kim, Yonghwan, Chul Kang, Ho, Kim, Hongtae
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735692/
https://ncbi.nlm.nih.gov/pubmed/26781088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10463
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