Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

Stromal fibroblast recruitment to tumours and activation to a cancer-associated fibroblast (CAF) phenotype has been implicated in promoting primary tumour growth and progression to metastatic disease. However, the mechanisms underlying the tumour:fibroblast crosstalk that drive the intertumoural str...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Avgustinova, Alexandra, Iravani, Marjan, Robertson, David, Fearns, Antony, Gao, Qiong, Klingbeil, Pamela, Hanby, Andrew M., Speirs, Valerie, Sahai, Erik, Calvo, Fernando, Isacke, Clare M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735631/
https://ncbi.nlm.nih.gov/pubmed/26777421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10305
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