Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects

MicroRNAs (miRNAs) are being developed to enhance tissue regeneration. Here we show that a hyperbranched polymer with high miRNA-binding affinity and negligible cytotoxicity can self-assemble into nano-sized polyplexes with a ‘double-shell' miRNA distribution and high transfection efficiency. T...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Zhang, Xiaojin, Li, Yan, Chen, Y. Eugene, Chen, Jihua, Ma, Peter X.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735608/
https://ncbi.nlm.nih.gov/pubmed/26765931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10376
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