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Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
MicroRNAs (miRNAs) are being developed to enhance tissue regeneration. Here we show that a hyperbranched polymer with high miRNA-binding affinity and negligible cytotoxicity can self-assemble into nano-sized polyplexes with a ‘double-shell' miRNA distribution and high transfection efficiency. T...
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| Gepubliceerd in: | Nat Commun |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4735608/ https://ncbi.nlm.nih.gov/pubmed/26765931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10376 |
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