Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

Hypoxia-inducible factor-1α (HIF-1α) mediates hypoxic responses and regulates gene expression involved in angiogenesis, invasion and metabolism. Among the various HIF-1α posttranslational modifications, HIF-1α methylation and its physiological role have not yet been elucidated. Here we show that HIF...

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Udgivet i:Nat Commun
Main Authors: Kim, Yunho, Nam, Hye Jin, Lee, Junyeop, Park, Do Young, Kim, Chan, Yu, Young Suk, Kim, Dongha, Park, Se Won, Bhin, Jinhyuk, Hwang, Daehee, Lee, Ho, Koh, Gou Young, Baek, Sung Hee
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735525/
https://ncbi.nlm.nih.gov/pubmed/26757928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10347
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