Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts

INTRODUCTION: Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in the gingiva, human gingival fibroblasts express...

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Vydáno v:PLoS One
Hlavní autoři: Williams, Rachel C., Skelton, Andrew J., Todryk, Stephen M., Rowan, Andrew D., Preshaw, Philip M., Taylor, John J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734666/
https://ncbi.nlm.nih.gov/pubmed/26829555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148024
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