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Suppression of NYVAC Infection in HeLa Cells Requires RNase L but Is Independent of Protein Kinase R Activity

Protein kinase R (PKR) and RNase L are host cell components that function to contain viral spread after infections. In this study, we analyzed the role of both proteins in the abortive infection of human HeLa cells with the poxvirus strain NYVAC, for which an inhibition of viral A27L and B5R gene ex...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Fernández-Escobar, Mercedes, Nájera, José Luis, Baldanta, Sara, Rodriguez, Dolores, Way, Michael, Esteban, Mariano, Guerra, Susana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734000/
https://ncbi.nlm.nih.gov/pubmed/26656695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02576-15
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