Host Response to the Attenuated Poxvirus Vector NYVAC: Upregulation of Apoptotic Genes and NF-κB-Responsive Genes in Infected HeLa Cells

NYVAC has been engineered as a safe, attenuated vaccinia virus (VV) vector for use in vaccination against a broad spectrum of pathogens and tumors. Due to the interest in NYVAC-based vectors as vaccines and current phase I/II clinical trials with this vector, there is a need to analyze the human hos...

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Bibliographic Details
Main Authors: Guerra, Susana, López-Fernández, Luis A., Pascual-Montano, Alberto, Nájera, José Luis, Zaballos, Angel, Esteban, Mariano
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346868/
https://ncbi.nlm.nih.gov/pubmed/16379000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.2.985-998.2006
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