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Digging deep into “dirty” drugs – modulation of the methylation machinery
DNA methylation and histone modification are epigenetic mechanisms that result in altered gene expression and cellular phenotype. The exact role of methylation in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) remains unclear. However, aberrations (e.g. loss-/gain-of-function or up...
में बचाया:
| में प्रकाशित: | Drug Metab Rev |
|---|---|
| मुख्य लेखकों: | , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Informa Healthcare
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733942/ https://ncbi.nlm.nih.gov/pubmed/25566693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03602532.2014.995379 |
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