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Digging deep into “dirty” drugs – modulation of the methylation machinery
DNA methylation and histone modification are epigenetic mechanisms that result in altered gene expression and cellular phenotype. The exact role of methylation in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) remains unclear. However, aberrations (e.g. loss-/gain-of-function or up...
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| Vydáno v: | Drug Metab Rev |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Informa Healthcare
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733942/ https://ncbi.nlm.nih.gov/pubmed/25566693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03602532.2014.995379 |
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