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MCR synthesis of a tetracyclic tetrazole scaffold

Scaffold diversity is key in the ongoing exercise of discovery of novel bioactive compounds using high throughput screening (HTS). Based on the Ugi tetrazole synthesis we have designed novel bi- and tri-cyclic scaffolds featuring interesting pharmacophore properties. The compounds of the scaffold (B...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Patil, Pravin, Khoury, Kareem, Herdtweck, Eberhardt, Dömling, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733496/
https://ncbi.nlm.nih.gov/pubmed/25630499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.12.021
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