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MCR synthesis of a tetracyclic tetrazole scaffold

Scaffold diversity is key in the ongoing exercise of discovery of novel bioactive compounds using high throughput screening (HTS). Based on the Ugi tetrazole synthesis we have designed novel bi- and tri-cyclic scaffolds featuring interesting pharmacophore properties. The compounds of the scaffold (B...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Patil, Pravin, Khoury, Kareem, Herdtweck, Eberhardt, Dömling, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733496/
https://ncbi.nlm.nih.gov/pubmed/25630499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.12.021
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