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RNF2 E3 or not to E3: Dual Roles of RNF2 Overexpression in Melanoma
RNF2/Ring1B is amplified and overexpressed in numerous tumors and contributes to tumorigenicity, however the biological importance is poorly understood. Surprisingly, the role of RNF2 in tumorigenesis and invasion can be separated into catalytically-independent and catalytically-dependent processes.
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| Publicado no: | Cancer Discov |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733319/ https://ncbi.nlm.nih.gov/pubmed/26637658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1285 |
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