Ablation of the Stimulatory G Protein α-Subunit in Renal Proximal Tubules Leads to Parathyroid Hormone-Resistance With Increased Renal Cyp24a1 mRNA Abundance and Reduced Serum 1,25-Dihydroxyvitamin D

PTH regulates serum calcium, phosphate, and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) levels by acting on bone and kidney. In renal proximal tubules (PTs), PTH inhibits reabsorption of phosphate and stimulates the synthesis of 1,25(OH)(2)D. The PTH receptor couples to multiple G proteins. We here ablat...

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Pubblicato in:Endocrinology
Autori principali: Zhu, Yan, He, Qing, Aydin, Cumhur, Rubera, Isabelle, Tauc, Michel, Chen, Min, Weinstein, Lee S., Marshansky, Vladimir, Jüppner, Harald, Bastepe, Murat
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2016
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733111/
https://ncbi.nlm.nih.gov/pubmed/26671181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1639
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