Transgenic Overexpression of the Extra-Large Gsα Variant XLαs Enhances Gsα-Mediated Responses in the Mouse Renal Proximal Tubule in Vivo

XLαs, a variant of the stimulatory G protein α-subunit (Gsα), can mediate receptor-activated cAMP generation and, thus, mimic the actions of Gsα in transfected cells. However, it remains unknown whether XLαs can act in a similar manner in vivo. We have now generated mice with ectopic transgenic expr...

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Bibliografiske detaljer
Main Authors: Liu, Zun, Segawa, Hiroko, Aydin, Cumhur, Reyes, Monica, Erben, Reinhold G., Weinstein, Lee S., Chen, Min, Marshansky, Vladimir, Fröhlich, Leopold F., Bastepe, Murat
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2011
Fag:
Calcium-Regulating Hormones
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060637/
https://ncbi.nlm.nih.gov/pubmed/21303955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-1034
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