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Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast

The structural diversity and biological activities of fungal indole diterpenes (IDTs) are generated in large part by the IDT cyclases (IDTCs). Identifying different IDTCs from IDT biosynthetic pathway is therefore important towards understanding how these enzymes introduce chemical diversity from a...

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發表在:J Am Chem Soc
Main Authors: Tang, Mancheng, Lin, Hsiao-Ching, Li, Dehai, Zou, Yi, Li, Jian, Xu, Wei, Cacho, Ralph A., Hillenmeyer, Maureen E., Garg, Neil K., Tang, Yi
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732561/
https://ncbi.nlm.nih.gov/pubmed/26469304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b06108
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