Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast

The structural diversity and biological activities of fungal indole diterpenes (IDTs) are generated in large part by the IDT cyclases (IDTCs). Identifying different IDTCs from IDT biosynthetic pathway is therefore important towards understanding how these enzymes introduce chemical diversity from a...

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Published in:J Am Chem Soc
Main Authors: Tang, Mancheng, Lin, Hsiao-Ching, Li, Dehai, Zou, Yi, Li, Jian, Xu, Wei, Cacho, Ralph A., Hillenmeyer, Maureen E., Garg, Neil K., Tang, Yi
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732561/
https://ncbi.nlm.nih.gov/pubmed/26469304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b06108
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