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Astrocyte Resilience to Oxidative Stress Induced by Insulin-like Growth Factor I (IGF-I) Involves Preserved AKT (Protein Kinase B) Activity

Disruption of insulin-like growth factor I (IGF-I) signaling is a key step in the development of cancer or neurodegeneration. For example, interference of the prosurvival IGF-I/AKT/FOXO3 pathway by redox activation of the stress kinases p38 and JNK is instrumental in neuronal death by oxidative stre...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Dávila, David, Fernández, Silvia, Torres-Alemán, Ignacio
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732231/
https://ncbi.nlm.nih.gov/pubmed/26631726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.695478
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