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Neuronal Death by Oxidative Stress Involves Activation of FOXO3 through a Two-Arm Pathway That Activates Stress Kinases and Attenuates Insulin-like Growth Factor I Signaling
Oxidative stress kills neurons by stimulating FOXO3, a transcription factor whose activity is inhibited by insulin-like growth factor I (IGF-I), a wide-spectrum neurotrophic signal. Because recent evidence has shown that oxidative stress blocks neuroprotection by IGF-I, we examined whether attenuati...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2366852/ https://ncbi.nlm.nih.gov/pubmed/18287535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-08-0811 |
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