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Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons
BACKGROUND: Friedreich’s ataxia (FRDA) is a neurodegenerative disease caused by deficiency of the mitochondrial iron chaperone frataxin (Fxn). FRDA has no cure, but disease-modifying strategies to increase frataxin are under study. Because insulin-like growth factor I (IGF-I) has therapeutic effects...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3547778/ https://ncbi.nlm.nih.gov/pubmed/23039828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-51 |
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