Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES

Epiregulin (EPR) is a ligand of the epidermal growth factor (EGF) family that upon binding to its epidermal growth factor receptor (EGFR) stimulates proliferative signaling, especially in colon cancer cells. Here, we describe the three-dimensional structure of the EPR antibody (the 9E5(Fab) fragment...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kado, Yuji, Mizohata, Eiichi, Nagatoishi, Satoru, Iijima, Mariko, Shinoda, Keiko, Miyafusa, Takamitsu, Nakayama, Taisuke, Yoshizumi, Takuma, Sugiyama, Akira, Kawamura, Takeshi, Lee, Young-Hun, Matsumura, Hiroyoshi, Doi, Hirofumi, Fujitani, Hideaki, Kodama, Tatsuhiko, Shibasaki, Yoshikazu, Tsumoto, Kouhei, Inoue, Tsuyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732215/
https://ncbi.nlm.nih.gov/pubmed/26627827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656009
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