At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody

Two non-human glycan epitopes, galactose-α-1,3-galactose (α-gal) and Neu5Gc-α-2-6-galactose (Neu5Gc) have been shown to be antigenic when attached to Fab oligosaccharides of monoclonal antibodies (mAbs) , while α-gal attached to Fc glycans was not. However, the antigenicity of Neu5Gc on the Fc glyca...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Yu, Chuanfei, Gao, Kai, Zhu, Lei, Wang, Wenbo, Wang, Lan, Zhang, Feng, Liu, Chunyu, Li, Meng, Wormald, Mark R., Rudd, Pauline M., Wang, Junzhi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731815/
https://ncbi.nlm.nih.gov/pubmed/26823113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20029
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