Naturally occurring proteinaceous nanoparticles in Coptidis Rhizoma extract act as concentration-dependent carriers that facilitate berberine absorption

Pharmacological activities of some natural products diminish and even disappear after purification. In this study, we explored the mechanisms underlying the decrease of acute oral toxicity of Coptidis Rhizoma extract after purification. The water solubility, in vitro absorption, and plasma exposure...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ma, Bing-Liang, Yin, Chun, Zhang, Bo-Kai, Dai, Yan, Jia, Yi-Qun, Yang, Yan, Li, Qiao, Shi, Rong, Wang, Tian-Ming, Wu, Jia-Sheng, Li, Yuan-Yuan, Lin, Ge, Ma, Yue-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731763/
https://ncbi.nlm.nih.gov/pubmed/26822920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20110
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