Naturally occurring proteinaceous nanoparticles in Coptidis Rhizoma extract act as concentration-dependent carriers that facilitate berberine absorption

Pharmacological activities of some natural products diminish and even disappear after purification. In this study, we explored the mechanisms underlying the decrease of acute oral toxicity of Coptidis Rhizoma extract after purification. The water solubility, in vitro absorption, and plasma exposure...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Ma, Bing-Liang, Yin, Chun, Zhang, Bo-Kai, Dai, Yan, Jia, Yi-Qun, Yang, Yan, Li, Qiao, Shi, Rong, Wang, Tian-Ming, Wu, Jia-Sheng, Li, Yuan-Yuan, Lin, Ge, Ma, Yue-Ming
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731763/
https://ncbi.nlm.nih.gov/pubmed/26822920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20110
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