Nuclear Hormone Receptor LXRα Inhibits Adipocyte Differentiation of Mesenchymal Stem Cells with Wnt/beta-catenin Signaling

Nuclear hormone receptor liver X receptor-alpha (LXRα) plays a vital role in cholesterol homeostasis and is reported to play a role in adipose function and obesity although this is controversial. Conversely, mesenchymal stem cells (MSCs) are suggested to be a major source of adipocyte generation. Ac...

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Veröffentlicht in:Lab Invest
Hauptverfasser: Matsushita, Kenichi, Morello, Fulvio, Zhang, Zhiping, Masuda, Tomoko, Iwanaga, Shiro, Steffensen, Knut R., Gustafsson, Jan-Åke, Pratt, Richard E., Dzau, Victor J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731266/
https://ncbi.nlm.nih.gov/pubmed/26595172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2015.141
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