MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus

Mesenchymal stem cell transplantation (MSCT) has been used to treat human diseases, but the detailed mechanisms underlying its success are not fully understood. Here we show that MSCT rescues bone marrow MSC (BMMSC) function and ameliorates osteopenia in Fas-deficient-MRL/lpr mice. Mechanistically,...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Liu, Shiyu, Liu, Dawei, Chen, Chider, Hamamura, Kazunori, Moshaverinia, Alireza, Yang, Ruili, Liu, Yao, Jin, Yan, Shi, Songtao
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731233/
https://ncbi.nlm.nih.gov/pubmed/26365178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.08.018
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