Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1

Histone demethylase upregulation has been observed in human cancers, yet it is unknown whether this is a bystander event or a driver of tumorigenesis. We found that overexpression of lysine-specific demethylase 4A (KDM4A, also known as JMJD2A) was positively correlated with Gleason score and metasta...

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Опубликовано в: :J Clin Invest
Главные авторы: Kim, Tae-Dong, Jin, Fang, Shin, Sook, Oh, Sangphil, Lightfoot, Stan A., Grande, Joseph P., Johnson, Aaron J., van Deursen, Jan M., Wren, Jonathan D., Janknecht, Ralf
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731184/
https://ncbi.nlm.nih.gov/pubmed/26731476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78132
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