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Regulation of Tumor Suppressor p53 and HCT116 Cell Physiology by Histone Demethylase JMJD2D/KDM4D

JMJD2D, also known as KDM4D, is a histone demethylase that removes methyl moieties from lysine 9 on histone 3 and from lysine 26 on histone 1.4. Here, we demonstrate that JMJD2D forms a complex with the p53 tumor suppressor in vivo and interacts with the DNA binding domain of p53 in vitro. A lucifer...

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Bibliografiske detaljer
Main Authors: Kim, Tae-Dong, Oh, Sangphil, Shin, Sook, Janknecht, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326058/
https://ncbi.nlm.nih.gov/pubmed/22514644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034618
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