TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome

Beckwith-Wiedemann syndrome (BWS) is a human stem cell disorder, and individuals with this disease have a substantially increased risk (~800-fold) of developing tumors. Epigenetic silencing of β2-spectrin (β2SP, encoded by SPTBN1), a SMAD adaptor for TGF-β signaling, is causally associated with BWS;...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Chen, Jian, Yao, Zhi-Xing, Chen, Jiun-Sheng, Gi, Young Jin, Muñoz, Nina M., Kundra, Suchin, Herlong, H. Franklin, Jeong, Yun Seong, Goltsov, Alexei, Ohshiro, Kazufumi, Mistry, Nipun A., Zhang, Jianping, Su, Xiaoping, Choufani, Sanaa, Mitra, Abhisek, Li, Shulin, Mishra, Bibhuti, White, Jon, Rashid, Asif, Wang, Alan Yaoqi, Javle, Milind, Davila, Marta, Michaely, Peter, Weksberg, Rosanna, Hofstetter, Wayne L., Finegold, Milton J., Shay, Jerry W., Machida, Keigo, Tsukamoto, Hidekazu, Mishra, Lopa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731168/
https://ncbi.nlm.nih.gov/pubmed/26784546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80937
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