Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation

Previously, we identified an adolescent idiopathic scoliosis susceptibility locus near human ladybird homeobox 1 (LBX1) and FLJ41350 by a genome-wide association study. Here, we characterized the associated non-coding variant and investigated the function of these genes. A chromosome conformation ca...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Guo, Long, Yamashita, Hiroshi, Kou, Ikuyo, Takimoto, Aki, Meguro-Horike, Makiko, Horike, Shin-ichi, Sakuma, Tetsushi, Miura, Shigenori, Adachi, Taiji, Yamamoto, Takashi, Ikegawa, Shiro, Hiraki, Yuji, Shukunami, Chisa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731154/
https://ncbi.nlm.nih.gov/pubmed/26820155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005802
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