Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma

High-risk neuroblastoma remains lethal in about 50% of patients despite multimodal treatment. Recent attempts to identify molecular targets for specific therapies have shown that Neuroblastoma RAS (NRAS) is significantly mutated in a small number of patients. However, few inhibitors for the potentia...

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Veröffentlicht in:PLoS One
Hauptverfasser: Kiessling, Michael K., Curioni-Fontecedro, Alessandra, Samaras, Panagiotis, Lang, Silvia, Scharl, Michael, Aguzzi, Adriano, Oldrige, Derek A., Maris, John M., Rogler, Gerhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731059/
https://ncbi.nlm.nih.gov/pubmed/26821351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147682
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