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Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability
Epilepsy or seizure disorder is among the least understood chronic medical conditions affecting over 65 million people worldwide. Here, we show that disruption of the polycystic kidney disease 2-like 1 (Pkd2l1 or Pkdl), encoding polycystin-L (PCL), a non-selective cation channel, increases neuronal...
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Publicado no: | Hum Mol Genet |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4731019/ https://ncbi.nlm.nih.gov/pubmed/26612203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv484 |
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