Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability

Epilepsy or seizure disorder is among the least understood chronic medical conditions affecting over 65 million people worldwide. Here, we show that disruption of the polycystic kidney disease 2-like 1 (Pkd2l1 or Pkdl), encoding polycystin-L (PCL), a non-selective cation channel, increases neuronal...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Yao, Gang, Luo, Chong, Harvey, Michael, Wu, Maoqing, Schreiber, Taylor H., Du, Yanjun, Basora, Nuria, Su, Xuefeng, Contreras, Diego, Zhou, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731019/
https://ncbi.nlm.nih.gov/pubmed/26612203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv484
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