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A general, enantioselective synthesis of N-alkyl terminal aziridines and C2-functionalized azetidines via organocatalysis

A short, high-yielding protocol involving the enantioselective α-chlorination of aldehydes has been developed for the enantioselective synthesis of C2-functionalized aziridines and N-alkyl terminal azetidines from a common intermediate. This methodology allows for the rapid preparation of functional...

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Detalhes bibliográficos
Publicado no:Tetrahedron Lett
Main Authors: Senter, Timothy J., O’Reilly, Matthew C., Chong, Katherine M., Sulikowski, Gary A., Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730893/
https://ncbi.nlm.nih.gov/pubmed/26834294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.01.140
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