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Ruthenium-Catalyzed Asymmetric Hydrohydroxyalkylation of Butadiene: The Role of the Formyl Hydrogen Bond in Stereochemical Control

The catalyst generated in situ from RuH(2)(CO)(PPh(3))(3), (S)-SEGPHOS, and a chiral phosphoric acid promotes asymmetric hydrohydroxyalkylation of butadiene and affords enantioenriched α-methyl homoallylic alcohols. The observed diastereo- and enantioselectivities are determined by both the chiral p...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Grayson, Matthew N., Krische, Michael J., Houk, K. N.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730892/
https://ncbi.nlm.nih.gov/pubmed/26107070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04844
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