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Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase

Missense mutations in spermine synthase (SpmSyn) protein have been shown to cause the Snyder-Robinson syndrome (SRS). Depending on the location within the structure of SpmSyn and type of amino acid substitution, different mechanisms resulting in SRS were proposed. Here we focus on naturally occurrin...

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Publicat a:Int J Mol Sci
Autors principals: Peng, Yunhui, Norris, Joy, Schwartz, Charles, Alexov, Emil
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730321/
https://ncbi.nlm.nih.gov/pubmed/26761001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17010077
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