A Second Generation 2-Methoxyestradiol Prodrug Is Effective Against Barrett's Adenocarcinoma in a Mouse Xenograft Model

2-Methoxyestradiol (2-ME2) is an endogenous metabolite of estradiol. In preclinical models, 2-ME2 is effective against different types of tumors. Unfortunately, only low systemic concentrations of 2-ME2 can be achieved following oral administration, even after very high doses are administered to pat...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Kambhampati, Suman, Rajewski, Roger A., Tanol, Mehmet, Haque, Inamul, Das, Amlan, Banerjee, Snigdha, Jha, Saheli, Burns, Douglas, Reyes, Emma Borrego-Diaz, Van Veldhuizen, Peter J., Banerjee, Sushanta K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729448/
https://ncbi.nlm.nih.gov/pubmed/23288782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0777
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