Exocytosis of Endothelial Lysosome-Related Organelles Hair-Triggers a Patchy Loss of Glycocalyx at the Onset of Sepsis

Sepsis is a systemic inflammatory syndrome induced by bacterial infection that can lead to multiorgan failure. Endothelial surface glycocalyx (ESG) decorating the inner wall of blood vessels is a regulator of multiple vascular functions. Here, we tested a hypothesis that patchy degradation of ESG oc...

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Udgivet i:Am J Pathol
Main Authors: Zullo, Joseph A., Fan, Jie, Azar, Tala T., Yen, Wanyi, Zeng, Min, Chen, Jun, Ratliff, Brian B., Song, Jun, Tarbell, John M., Goligorsky, Michael S., Fu, Bingmei M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2016
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729233/
https://ncbi.nlm.nih.gov/pubmed/26683662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.10.001
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