Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication

The programmed −1 ribosomal frameshifting (−1 PRF) utilized by eukaryotic RNA viruses plays a crucial role for the controlled, limited synthesis of viral RNA replicase polyproteins required for genome replication. The viral RNA replicase polyproteins of severe acute respiratory syndrome coronavirus...

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Bibliographic Details
Published in:Antiviral Res
Main Authors: Ahn, Dae-Gyun, Lee, Wooseong, Choi, Jin-Kyu, Kim, Seong-Jun, Plant, Ewan P., Almazán, Fernando, Taylor, Deborah R., Enjuanes, Luis, Oh, Jong-Won
Format: Artigo
Language:Inglês
Published: Elsevier B.V. Published by Elsevier B.V. 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728714/
https://ncbi.nlm.nih.gov/pubmed/21549154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2011.04.009
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