Blood–brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P‐glycoprotein on a novel verapamil influx carrier

BACKGROUND AND PURPOSE: The respective impact and interplay between ABC (P‐glycoprotein/P‐gp/Abcb1a, BCRP/ABCG2, MRP/ABCC) and SLC transporter functions at the blood–brain barrier (BBB) and blood–retinal barriers (BRB) are incompletely understood. EXPERIMENTAL APPROACH: We measured the initial cereb...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Chapy, Hélène, Saubaméa, Bruno, Tournier, Nicolas, Bourasset, Fanchon, Behar‐Cohen, Francine, Declèves, Xavier, Scherrmann, Jean‐Michel, Cisternino, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728421/
https://ncbi.nlm.nih.gov/pubmed/26507673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13376
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